Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia.

@article{Hara1988ComparisonOT,
  title={Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia.},
  author={Junichi Hara and Stephen H. Benedict and Eric Champagne and Tak W Mak and Michael Minden and ErwinW. Gelfand},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={81 4},
  pages={
          989-96
        }
}
We have analyzed the configuration of the T cell receptor (TCR) alpha gene using newly developed genomic joining region (J alpha) probes, which cover approximately 80 kb of the J alpha region upstream from the constant region in 19 patients with T cell acute lymphoblastic leukemia (T-ALL) and in three CD3- leukemic T cell lines (HSB2, CEM, and MOLT4). In parallel, transcription of the TCR-alpha, beta, and gamma genes was examined in 11 of these patients and in the T cell lines. All T-ALL and… CONTINUE READING
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