Comparison of T cell immune responses induced by vectored HIV vaccines in non-human primates and humans.

  title={Comparison of T cell immune responses induced by vectored HIV vaccines in non-human primates and humans.},
  author={Andrew J. Bett and Sheri A. Dubey and Devan V. Mehrotra and Liming Guan and Romnie S. Long and Kiersten Anderson and Kelly L. Collins and Christine Gaunt and Rose Fernandez and Suzanne Cole and Steve Meschino and Aimin Tang and Xiao Xia Sun and Sanjay Gurunathan and Jim Tartaglia and Michael N. Robertson and John Shiver and Danilo R. Casimiro},
  volume={28 50},
Following the disappointing outcome of the phase IIb test-of-concept step study in which Merck's adenovirus type 5 (Ad5) HIV-1 clade B gag/pol/nef vaccine failed to demonstrate efficacy in HIV high-risk individuals, an extensive review of the trial and preclinical studies which supported the trial is ongoing. One point of interest is how well preclinical nonhuman primate immunogenicity studies predicted what was observed in humans. Here we compare the HIV-1-specific cellular immune responses… CONTINUE READING
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