Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

@article{Bartelt2009ComparisonOT,
  title={Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells},
  author={Rebekah Ruth Bartelt and Noemi Cruz-Orcutt and Michaela Collins and Jon C D Houtman},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={758 - 770}
}
BACKGROUND Human T cells play an important role in pathogen clearance, but their aberrant activation is also linked to numerous diseases. T cells are activated by the concurrent induction of the T cell receptor (TCR) and one or more costimulatory receptors. The characterization of signaling pathways induced by TCR and/or costimulatory receptor activation is critical, since these pathways are excellent targets for novel therapies for human disease. Although studies using human T cell lines have… CONTINUE READING

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