Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures.

@article{Griffith2016ComparisonOS,
  title={Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures.},
  author={Lauren E Griffith and Edwin R van den Heuvel and Parminder Raina and Isabel Fortier and Nazmul Sohel and Scott M. Hofer and H{\'e}l{\`e}ne A Payette and Christina Wolfson and Sylvie Belleville and Meghan Kenny and Dany Doiron},
  journal={American journal of epidemiology},
  year={2016},
  volume={184 10},
  pages={
          770-778
        }
}
Standardization procedures are commonly used to combine phenotype data that were measured using different instruments, but there is little information on how the choice of standardization method influences pooled estimates and heterogeneity. Heterogeneity is of key importance in meta-analyses of observational studies because it affects the statistical models used and the decision of whether or not it is appropriate to calculate a pooled estimate of effect. Using 2-stage individual participant… CONTINUE READING