Comparison of SSRIs and SNRIs in major depressive disorder: a meta‐analysis of head‐to‐head randomized clinical trials
@article{Machado2010ComparisonOS,
title={Comparison of SSRIs and SNRIs in major depressive disorder: a meta‐analysis of head‐to‐head randomized clinical trials},
author={M{\'a}rcio Machado and Thomas R Einarson},
journal={Journal of Clinical Pharmacy and Therapeutics},
year={2010},
volume={35}
}Context: Controversy exists whether serotonin–norepinephrine reuptake inhibitors (SNRIs) have improved efficacy compared with selective serotonin reuptake inhibitors (SSRIs).
34 Citations
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Current evidence suggests that treatment with duloxetine may be beneficial in older adults with major depressive disorder, and its pharmacological properties are summarized.
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It will be not surprising to predict the potential success of ALKS 5461 (a combination of buprenorphine and ALKS-33) in the near future and CERC-501 will be expected to be available as monotherapy or adjuvant therapy with other first-line antidepressants in the treatment of TRD, if ongoing clinical trials continue to provide positive benefit-risk profiles.
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- Medicine, Psychology
- 2017
Analysis showed that SSRIs and SNRIs were significantly more beneficial compared with placebo, yielding a small effect size for ADs, while patients receiving an antidepressant reported significantly more treatment-emergent adverse events.
Health resource use and costs of vilazodone and other selective serotonin re-uptake inhibitors in treating major depressive disorder
- Medicine, PsychologyJournal of medical economics
- 2015
MDD treatment with vilazodone was associated with significantly lower rates of inpatient and emergency services, and with significant lower all-cause medical service costs and numerically (non-significantly) lower total costs to payers than with the other SSRIs included in this study.
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- Medicine, Psychology
- 2014
Evaluated SNRI and SSRI are both evidence-based choices for induction of remission in depression and the choice of a SNRI over a SSRI to achieve remission of depression is not supported by the current evidence.
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- Psychology, MedicineJAMA psychiatry
- 2017
Compared with placebo, SSRIs and SNRIs are more beneficial than placebo in children and adolescents; however, the benefit is small and disorder specific, yielding a larger drug-placebo difference for AD than for other conditions.
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- 2011
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Efficacy of acupuncture treatment of sexual dysfunction secondary to antidepressants.
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- 2013
A potential role for acupuncture is suggested in the treatment of the sexual side-effects of SSRIs and SNRIs as well for a potential benefit of integrating medical and complementary and alternative practitioners.
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The annual Latest Advances in Psychiatry Symposium provided an update on topics from eating disorders and problem gambling to management guidelines for schizophrenia and depression, and attention deficit hyperactivity disorder (ADHD) in adults.
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