Comparison of SP-A and LPS effects on the THP-1 monocytic cell line.

@article{Song2000ComparisonOS,
  title={Comparison of SP-A and LPS effects on the THP-1 monocytic cell line.},
  author={Myungsun Song and David S. Phelps},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={279 1},
  pages={
          L110-7
        }
}
Surfactant protein A (SP-A) increases production of proinflammatory cytokines by monocytic cells, including THP-1 cells, as does lipopolysaccharide (LPS). Herein we report differences in responses to these agents. First, polymyxin B inhibits the LPS response but not the SP-A response. Second, SP-A-induced increases in tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-8 are reduced by >60% if SP-A is preincubated with Survanta (200 microgram/ml) for 15 min before… CONTINUE READING
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Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect.

American journal of physiology. Lung cellular and molecular physiology • 2002
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