Comparison of Risperidone and Mosapramine Addition to Neuroleptic Treatment in Chronic Schizophrenia

@article{Takahashi1999ComparisonOR,
  title={Comparison of Risperidone and Mosapramine Addition to Neuroleptic Treatment in Chronic Schizophrenia},
  author={Norito Takahashi and Takeshi Terao and Tetsuo Oga and Masakatsu Okada},
  journal={Neuropsychobiology},
  year={1999},
  volume={39},
  pages={81 - 85}
}
There is little information regarding the effects of risperidone addition to neuroleptic treatment in chronic schizophrenia. As a preliminary study, 10 neuroleptic-treated schizophrenic inpatients received risperidone (high 5HT2A/D2 ratio, i.e. the ratio between 5HT2A and D2 receptor occupancy) and mosapramine (low 5HT2A/D2 ratio) in a randomized, single-blind, crossover, add-on study consisting of 8 weeks of treatment each with risperidone and mosapramine. Although both additions resulted in… 

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