Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions

@inproceedings{Schmal2018ComparisonOR,
  title={Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions},
  author={Hagen Schmal and Justyna M. Kowal and Moustapha Kassem and Michael Seidenstuecker and Anke Bernstein and Katharina B{\"o}ttiger and Tanshiyue Xiong and Norbert P Suedkamp and Eva Johanna Kubosch},
  booktitle={Stem cells international},
  year={2018}
}
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a… CONTINUE READING

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