Comparison of Protein-Protein Interaction Confidence Assignment Schemes

  title={Comparison of Protein-Protein Interaction Confidence Assignment Schemes},
  author={Silpa Suthram and Tomer Shlomi and Eytan Ruppin and Roded Sharan and Trey Ideker},
  booktitle={Systems Biology and Regulatory Genomics},
Recent technological advances have enabled high-throughput measurements of protein-protein interactions in the cell, producing protein interaction networks for various species at an ever increasing pace. However, common technologies like yeast two-hybrid can experience high rates of false positive detection. To combat these errors, many methods have been developed which associate confidence scores with each interaction. Here we perform the first comparative analysis and performance assessment… CONTINUE READING


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