Comparison of Pharmacokinetics of Puerain Between Normal and Alzheimer's Disease Model Rats Induced by β Amyloid Peptide

@inproceedings{Qinian2011ComparisonOP,
  title={Comparison of Pharmacokinetics of Puerain Between Normal and Alzheimer's Disease Model Rats Induced by β Amyloid Peptide},
  author={Bao Qi-nian},
  year={2011}
}
Objective:To study the pharmacokinetics of puerarin in normal and AD rats induced by β amyloid peptide.Methods:Animals models of AD was successfully induced in rats by trace injection of β amyloid peptide on basal nuclei,given puerarin injection oral 500mg/kg 7 days later.The normal control group were given the equivalent dose drug.The concentrations of puerarin in plasma at different times were determined by RP-HPLC.The pharmacokinetic parameters were accessed by 3P87.Results:Puerarin was… CONTINUE READING

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