Comparison of Peptides Eluted from the Groove of HLA-B27 from Salmonella Infected and Non-Infected Cells

@article{Ringrose1996ComparisonOP,
  title={Comparison of Peptides Eluted from the Groove of HLA-B27 from Salmonella Infected and Non-Infected Cells},
  author={Jeffrey H. Ringrose and Beverley A. Yard and Anton O. Muijsers and Claire J. P. Boog and Theodorus E W Feltkamp},
  journal={Clinical Rheumatology},
  year={1996},
  volume={15},
  pages={74-78}
}
Reactive arthritis (ReA) is associated with the MHC class- I molecule HLA- B27 and caused by certain Gram- negative bacteria. The mechanism by which HLA- B27 confers a higher susceptibility for this disease compared to other MHC Class-I alleles is still not known. We investigated whether infection of human HLA- B27+ cells is able to change the peptide repertoire presented by these HLA- B27 molecules. To this end large quantities of a B- cell line (C1R- B27) transfected with HLA- B2705 were… CONTINUE READING
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