Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

@inproceedings{Greaves2012ComparisonOM,
  title={Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations},
  author={Laura C. Greaves and Joanna L Elson and Marco Nooteboom and John P Grady and Geoffrey A. Taylor and Robert W Taylor and John C. Mathers and Thomas B. L. Kirkwood and Douglass Matthew Turnbull},
  booktitle={PLoS genetics},
  year={2012}
}
Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whether there are selective constraints, which have been shown to occur in the germline, on the occurrence and expansion of these mtDNA mutations within individual somatic cells. Here we compared the… CONTINUE READING
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A Human Mitochondrial Genome Database

  • MITOMAP
  • http://www. mitomap.org
  • 2011
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