Comparison of Methods for Competitive Tests of Pathway Analysis

  title={Comparison of Methods for Competitive Tests of Pathway Analysis},
  author={Marina Evangelou and Augusto Rendon and Willem H Ouwehand and Lorenz Wernisch and Frank Dudbridge},
  booktitle={PloS one},
It has been suggested that pathway analysis can complement single-SNP analysis in exploring genomewide association data. Pathway analysis incorporates the available biological knowledge of genes and SNPs and is expected to improve the chances of revealing the underlying genetic architecture of complex traits. Methods for pathway analysis can be classified as competitive (enrichment) or self-contained (association) according to the hypothesis tested. Although association tests are statistically… CONTINUE READING


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