Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices.

@article{Duan2015ComparisonOM,
  title={Comparison of Mesenchymal Stem Cell Source Differentiation Toward Human Pediatric Aortic Valve Interstitial Cells within 3D Engineered Matrices.},
  author={Bin Duan and Laura Ann Hockaday and Shoshana L Das and Charlie Xu and Jonathan T. Butcher},
  journal={Tissue engineering. Part C, Methods},
  year={2015},
  volume={21 8},
  pages={
          795-807
        }
}
Living tissue-engineered heart valves (TEHV) would be a major benefit for children who require a replacement with the capacity for growth and biological integration. A persistent challenge for TEHV is accessible human cell source(s) that can mimic native valve cell phenotypes and matrix remodeling characteristics that are essential for long-term function. Mesenchymal stem cells derived from bone marrow (BMMSC) or adipose tissue (ADMSC) are intriguing cell sources for TEHV, but they have not… CONTINUE READING
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