Comparison of Mechanism and Functional Effects of Magnesium and Statin Pharmaceuticals

@article{Rosanoff2004ComparisonOM,
  title={Comparison of Mechanism and Functional Effects of Magnesium and Statin Pharmaceuticals},
  author={Andrea Rosanoff and Mildred S. Seelig},
  journal={Journal of the American College of Nutrition},
  year={2004},
  volume={23},
  pages={501S - 505S}
}
Since Mg2+-ATP is the controlling factor for the rate-limiting enzyme in the cholesterol biosynthesis sequence that is targeted by the statin pharmaceutical drugs, comparison of the effects of Mg2+ on lipoproteins with those of the statin drugs is warranted. Formation of cholesterol in blood, as well as of cholesterol required in hormone synthesis, and membrane maintenance, is achieved in a series of enzymatic reactions that convert HMG-CoA to cholesterol. The rate-limiting reaction of this… 
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