Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths

@article{Rohrer2005ComparisonOM,
  title={Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths},
  author={Martin Rohrer and Hans Bauer and Jan Mintorovitch and Martin Requardt and Hanns J. Weinmann},
  journal={Investigative Radiology},
  year={2005},
  volume={40},
  pages={715-724}
}
Rationale and Objectives:To characterize and compare commercially available contrast media (CM) for magnetic resonance imaging (MRI) in terms of their relaxivity at magnetic field strengths ranging from 0.47 T to 4.7 T at physiological temperatures in water and in plasma. Relaxivities also were quantified in whole blood at1.5 T. Methods:Relaxivities of MRI-CM were determined by nuclear magnetic resonance (NMR) spectroscopy at 0.47 T and MRI phantom measurements at 1.5 T, 3 T, and 4.7 T… 

Aqueous paramagnetic solutions for MRI phantoms at 3 T: A detailed study on relaxivities

The main goal of this study is to measure r1 and r2 relaxivities of three common paramagnetic agents (CuSO4, MnCl2 , and NiCl2) at room temperature at 3 T, and to serve as a practical reference to design phantoms of target T1 and T2 values at3 T, in particularPhantoms with relaxation times equivalent to specific human tissues.

In Vitro Longitudinal Relaxivity Profile of Gd(ABE-DTTA), an Investigational Magnetic Resonance Imaging Contrast Agent

The longitudinal relaxivity of Gd(ABE-DTTA) measured within the presently clinically relevant field range is three to five times higher than that of most commercially available agents and could be a practical choice at any field strength currently used in clinical imaging including those at the higher end.

Gadolinium-Based Magnetic Resonance Contrast Agents at 7 Tesla: In Vitro T1 Relaxivities in Human Blood Plasma

At 7 Tesla, the in vitro r1 relaxivities of Gd-based contrast agents in human blood plasma are lower than those at 3 Tesla, which may serve as a basis for the application of G d-based MR contrast agents at 7 Tesla.

Magnetic field distribution and relaxation effects in the presence of interstitial and intracellular contrast agents for magnetic resonance imaging

A profound and systematic understanding of magnetic susceptibility and relaxation effects of interstitial and intracellular contrast agents in MRI is achieved.

Effect of r₁ and r₂ relaxivity of gadolinium-based contrast agents on the T₁-weighted MR signal at increasing magnetic field strengths.

The maximal available contrast enhancement (maxCE) was evaluated in absolute terms with the purpose of assessing how much of the full, underlying magnetization can be exploited, for a wide range of compound properties.

The issues and tentative solutions for contrast-enhanced magnetic resonance imaging at ultra-high field strength.

The aim of this review article is to provide an overview of the basic principles of MR contrast enhancement processes and to highlight the main factors influencing relaxivity.

Investigation in to the Effect of Spin Locking on Contrast Agent Relaxivity

A method that affords improved relaxivities of current clinically approved CAs, particularly at high B0 fields, that could be adopted into clinical practice rapidly, is of great interest.

Design of a fast field-cycling magnetic resonance imaging system, characterization and methods for relaxation dispersion measurements around 1.5 T.

The developments and performances of a device designed for small animal FFC-MRI comprising a resistive insert technology operating inside a 1.5 T MRI system are reported, opening the way to quantitative preclinical dispersion imaging studies at a high F FC-MRI field.

Susceptibility weighted imaging at ultra high magnetic field strengths: Theoretical considerations and experimental results

We present numerical simulations and experimental results for susceptibility weighted imaging (SWI) at 7 T. Magnitude, phase, and SWI contrast were simulated for different voxel geometries and

Enhancement Effect of Superparamagnetic Iron Oxide Nanoparticle-Based MRI Contrast Agent at Different Concentrations and Magnetic Field Strengths

Magnetic Resonance Imaging Contrast Agents (MRI-CM) are significant in the clinical and biological imaging as they have the ability to alter the normal tissue contrast, thereby affecting the signal
...

Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid.

It is demonstrated that a single measurement of relaxation times after contrast-enhanced magnetic resonance imaging could be used to determine the Gd-DTPA concentration in CSF, and it may be feasible, using this technique, to measure intersubject and intraregional variability in the quantity of Gd -DTPA transferred across the blood-brain barrier after intravenous injection of contrast agent.

Field strength and dose dependence of contrast enhancement by gadolinium-based MR contrast agents

Abstract. The relaxivities r1 and r2 of magnetic resonance contrast agents and the T1 relaxation time values of tissues are strongly field dependent. We present quantitative data and simulations of

Multinuclear magnetic resonance characterization of paramagnetic contrast agents. The manifold effects of concentration and counterions.

This study shows that NMR analyses of small molecular weight complexes should be carried out on solutions containing no more than 50 mM to avoid the biaising effects of concentration and tau R values obtained by proton NMRD analysis and by deuterium relaxation are in good agreement.

The effects of paramagnetic contrast agents on metabolite protons in aqueous solution.

The longitudinal (R1) and transverse (R2) relaxivities of the clinically used contrast agents Gd(DTPA)2-, Gd(DOTA)- and Gd(DTPA-BMA) have been determined in mixed aqueous metabolite solutions for

T1 effects of a bolus-injectable superparamagnetic iron oxide, SH U 555 A: dependence on field strength and plasma concentration--preliminary clinical experience with dynamic T1-weighted MR imaging.

Signal intensity changes at dynamic T1-weighted MR imaging after bolus injection of SH U 555 A can be explained by dynamic changes in iron-plasma concentration.

Studies of Gd‐DTPA relaxivity and proton exchange rates in tissue

The goal of this study was to characterize the compartmental tissue Gd‐DTPA relaxivities and to determine the proton exchange rate between the compartments, supporting the conclusion of fast cellular‐extracellular exchange.

Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging.

Weak protein binding can substantially increase the efficacy of gadolinium chelates as general purpose contrast agents for MRI.
...