Comparison of MS(2)-only, MSA, and MS(2)/MS(3) methodologies for phosphopeptide identification.

@article{Ulintz2009ComparisonOM,
  title={Comparison of MS(2)-only, MSA, and MS(2)/MS(3) methodologies for phosphopeptide identification.},
  author={Peter J. Ulintz and Anastasia K. Yocum and Bernd Bodenmiller and Ruedi Aebersold and Philip C. Andrews and Alexey I. Nesvizhskii},
  journal={Journal of proteome research},
  year={2009},
  volume={8 2},
  pages={887-99}
}
Current mass spectrometers provide a number of alternative methodologies for producing tandem mass spectra specifically for phosphopeptide analysis. In particular, generation of MS(3) spectra in a data-dependent manner upon detection of the neutral loss of a phosphoric acid in MS(2) spectra is a popular technique for circumventing the problem of poor phosphopeptide backbone fragmentation. The newer Multistage Activation method provides another option. Both these strategies require additional… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…