Comparison of Li-Wong and loglinear mixed models for the statistical analysis of oligonucleotide arrays

@article{Chu2004ComparisonOL,
  title={Comparison of Li-Wong and loglinear mixed models for the statistical analysis of oligonucleotide arrays},
  author={Tzu-Ming Chu and B. S. Weir and Russell D. Wolfinger},
  journal={Bioinformatics},
  year={2004},
  volume={20 4},
  pages={500-6}
}
MOTIVATION Li and Wong have described some useful statistical models for probe-level, oligonucleotide array data based on a multiplicative parametrization. In earlier work, we proposed similar analysis-of-variance-style mixed models fit on a log scale. With only subtle differences in the specification of their mean and stochastic error components, a question arises as to whether these models could lead to varying conclusions in practical application. RESULTS In this paper, we provide an… CONTINUE READING

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