Comparison of Inhibitory Functioning in Mild Alzheimer's Disease and Frontotemporal Dementia

@article{Collette2007ComparisonOI,
  title={Comparison of Inhibitory Functioning in Mild Alzheimer's Disease and Frontotemporal Dementia},
  author={Fabienne Collette and H{\'e}l{\`e}ne Ami{\`e}va and Stephane Adam and Michel Hogge and Martial Van der Linden and C. Fabrigoule and Eric Salmon},
  journal={Cortex},
  year={2007},
  volume={43},
  pages={866-874}
}
Executive dysfunction is frequently reported in Alzheimer's disease (AD) and the frontal variant of frontotemporal dementia (FTD). More specifically, inhibitory dysfunction is observed early in AD and inhibitory deficits are also prominent in patients with FTD. However, few studies have simultaneously explored and compared inhibitory abilities in both degenerative diseases. Consequently, the aim of this study was to compare verbal and motor inhibitory processes in the initial stages of AD and… Expand
A comparison of memory and executive functions in Alzheimer disease and the frontal variant of frontotemporal dementia.
TLDR
Qualitative analysis of errors in the B-P task indicated that both ADs and fvFTDs presented a higher number of omissions and perseverations, interpreted in this study as an index of executive dysfunction, compared to the control group. Expand
Inhibition impairment in frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer’s disease: clinical assessment and metabolic correlates
TLDR
Inhibition ability was mainly impaired in bvFTD and AD, and it correlated with the bilateral frontal lobe metabolism, which may support the concept of inhibition as a multidimensional construct, with the involvement of common and divergent neural mechanisms. Expand
Quantitative and qualitative features of executive dysfunction in frontotemporal and Alzheimer’s dementia
TLDR
There is substantial overlap in executive dysfunction between those with b vFTD and AD, though individuals with bvFTD tend to demonstrate worse letter fluency performance. Expand
Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease: A Neuropsychological and Behavioural Investigation
TLDR
The results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics. Expand
Language, executive function and social cognition in the diagnosis of frontotemporal dementia syndromes
TLDR
This review has attempted to delineate how language, executive function, and social cognition may contribute to the diagnosis of FTD syndromes, namely the behavioural variant FTD as well as the language variants ofFTD including the three subtypes of primary progressive aphasia (PPA): non-fluent/agrammatic, semantic and logopenic. Expand
Inhibitory Dysfunction in Frontotemporal Dementia: A Review
TLDR
It is suggested that improved characterization of early inhibitory dysfunction may facilitate more accurate diagnosis of frontotemporal dementia and explore inhibitory functioning in FTD through nonverbal experimental tasks. Expand
A Meta-Analysis of Inhibitory-Control Deficits in Patients Diagnosed With Alzheimer's Dementia
TLDR
Although the error rate results suggest a specific deterioration of inhibitory-control abilities in AD, further processes beyond inhibitory control appear to contribute to AD patients’ performance deficits observed on a variety of inhibitories-control tasks. Expand
A short neuropsychologic and cognitive evaluation of frontotemporal dementia
TLDR
The neuropsychological tests allow the differentiation between FTD and AD and the combination of FAB test with the assessment of key behavioural and cognitive symptoms appears helpful in this distinction. Expand
Executive deficits are related to the inferior frontal junction in early dementia
TLDR
The analysis consistently showed that hypometabolism in one region in the left lateral prefrontal cortex—the inferior frontal junction area—was related to performance in the various neuropsychological tests, underlines the importance of the inferior frontal Junction area for cognitive control in general and for executive deficits in early dementia. Expand
Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia
TLDR
This study adds support to the hypothesis that impulsivity in PD is not solely mediated by dopaminergic medication effects, but that fronto-striatal structural abnormalities contribute to impulsive behaviours in these patients. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 98 REFERENCES
Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia.
TLDR
Examination of relative rankings of scores across cognitive domains, in addition to interpretation of individual neuropsychological scores, may be useful in differential diagnosis of FTD versus AD. Expand
Inhibitory functioning in Alzheimer's disease.
TLDR
It was found that whilst most inhibitory mechanisms are affected by the disorder, some are relatively preserved, suggesting that inhibitory deficits in Alzheimer's disease may not be the result of a general inhibitory breakdown. Expand
Inhibitory Breakdown and Dementia of the Alzheimer Type: A General Phenomenon?
TLDR
The results showed that DAT patients failed to produce Negative Priming effects and were severely impaired in the Stroop task, suggesting that in the early stages of the disease, not all inhibitory mechanisms are uniformly impaired. Expand
Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease.
TLDR
The Frontal Assessment Battery takes less than 10 minutes to administer and provides an objective measure to distinguish FTD from AD in mildly demented patients and was optimal to differentiate both disorders. Expand
Specificity of inhibitory deficits in normal aging and Alzheimer's disease
TLDR
It is demonstrated that (1) there is an alteration of the inhibitory process in normal elderly subjects; (2) inhibitory and interference resolution processes are quantitately less efficient in AD, since these patients present a correct performance only for information which leaves weak traces in memory. Expand
Psychometric characteristics in patients with frontal lobe degeneration of non-Alzheimer type.
TLDR
Cognitive dysfunction was less severe in patients with onset of dementia below the age of 56 years as compared to patients with later onset, i.e., 56 years or older, while receptive speech functions were relatively less frequently affected. Expand
Differentiating frontal and temporal variant frontotemporal dementia from Alzheimer’s disease
TLDR
The double dissociation in performance on semantic memory and attention/executive function clearly separated the temporal and frontal variants ofFTD and aids the early differentiation of FTD from AD. Expand
Executive Dysfunction in Alzheimer's Disease
TLDR
The results showed that AD patients present lower performance compared to control subjects in all executive tasks, confirming that some executive deficits may be present in the first stages of the disease. Expand
Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis.
  • L. Gustafson
  • Medicine
  • Archives of gerontology and geriatrics
  • 1987
TLDR
In a longitudinal prospective study of dementia, 158 patients were investigated post mortem and the typical clinical picture was that of a slowly progressive dementia, at an early stage dominated by personality change, lack of insight, disinhibition, and later on stereotypy and increased apathy. Expand
Frontal Hypometabolism Does Not Explain Inhibitory Dysfunction in Alzheimer Disease
TLDR
The data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease, and that inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas. Expand
...
1
2
3
4
5
...