Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis

@article{Giannini1984ComparisonOH,
  title={Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis},
  author={A. Giannini and M. S. Eighan and R. H. Loiselle and M. Giannini},
  journal={The Journal of Clinical Pharmacology},
  year={1984},
  volume={24}
}
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below. 
Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.
TLDR
The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role. Expand
Absence of response to histamine1 blockade in phencyclidine toxicity.
TLDR
Chlorpromazine’s superiority over haloperidol in reducing anxiety and tension is contrary to what one would expect on the basis of anticholinergic activity alone. Expand
Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol.
TLDR
Results of haloperidol treatment of PHP psychosis were similar to previously published reports with phencyclidine (PCP) psychosis. Expand
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
: The authors studied 40 white men with acute phencyclidine (PCP) intoxication. On a random basis, 10 were treated with ascorbic acid, 10 with placebo, 10 with haloperidol, and 10 with a combinationExpand
Dopamine agonist action of phencyclidine
TLDR
A strong dopamine‐like agonist action at the functional high‐affinity state of the dopamine D2 receptor by the phencyclidine psychotomimetic is consistent with the dopamine hypothesis of psychosis. Expand
Treatment of Depression in Chronic Cocaine and Phencyclidine Abuse With Desipramine
TLDR
Subjects who received desipramine showed a decrease in depressive symptoms after a 20–40 day period regardless of whether they abused PCP or cocaine. Expand
The Ideal Antipsychotic: Hybrid between Typical Haloperidol And the Atypical Clozapine Antipsychotic
TLDR
The design of a “hybrid structure” having the desired properties of haloperidol and clozapine is proposed, with the intention being to find an optimal antipsychotic agent that exerts efficient therapeutic effects against both positive and negative symptoms of psychosis causing least possible side effects, such as in monotherapy. Expand
The psychotomimetic effects of PCP , LSD and MDMA : Pharmacological models of schizophrenia ?
In this Review the potential role of glutamatergic and serotonergic neurotransmitter systems in the pathophysiology of schizophrenia is examined from the perspective of the psychotomimetic effects ofExpand
Effect of repeated haloperidol administration on phencyclidine discrimination in rats
  • J. Wiley
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1995
TLDR
The results of this study suggest that repeated administration of haloperidol may disrupt PCP's discriminative stimulus effects, although most rats were still able to discriminate the higher doses of PCP. Expand
The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia
TLDR
To support the contention that NMDA receptor antagonist administration represents a viable model of schizophrenia, the behavioral and neurobiological effects of these drugs are discussed, especially with regard to differing profiles following single-dose and long-term exposure. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 13 REFERENCES
Physostigmine and haloperidol treatment of acute phencyclidine intoxication.
Twenty-four patients with phencyclidine intoxication were treated with either physostigmine (2 mg i.m.) or haloperidol (5 mg i.m.) based on the presence of delusions and/or hallucinations. SeveralExpand
Dopamine receptors, neuroleptics, and schizophrenia.
  • S. Snyder
  • Medicine
  • The American journal of psychiatry
  • 1981
TLDR
The binding of 3H-butyrophenones to dopamine receptors can be used for a radioreceptor assay that detects blood levels of all clinically used neuroleptics and their pharmacologically active metabolites and may facilitate routine monitoring of blood levels. Expand
Interaction of phencyclidines with the muscarinic and opiate receptors in the central nervous system
TLDR
Phencyclidine produces long-lasting psychosis thought to resemble schizophrenia more than any produced by other psychedelics 1~ and exaggerates psychopathology. Expand
Phencyclidine intoxication: assessment of possible antidotes.
TLDR
Recently it was found that intramuscular physostigmine and haloperidol improved several symptoms of acute PCP intoxication as measured by the Brief Psychiatric Rating Scale (BPRS). Expand
Specific [3H]phencyclidine binding in rat central nervous system.
  • S. Zukin, R. Zukin
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1979
TLDR
[3H]PCP binding was most enriched in crude synaptosomal subcellular fractions, and was about three times higher in hippocampus than in cervical spinal cord, suggesting that PCP may exert its effects on the central nervous system via binding to specific brain receptor sites. Expand
Dopamine Receptors: A Classification
  • I. Creese, S. Leff
  • Psychology, Medicine
  • Journal of clinical psychopharmacology
  • 1982
TLDR
Guanine nucleotides shift this equilibrium toward the low affinity state, and they likely play an important role in the regulation of dopamine agonist-stimulated physiological responses. Expand
Thin-Layer Chromatographic Screening and Confirmation of Phencyclidine In Urine
Experimental A thin-layer chromatographic method for the simultaneous screening and confirmation of phencyclidine In urine specimens Is presented. Urine specimens ere made basic and extracted withExpand
The Brief Psychiatric Rating Scale
The Brief Psychiatric Rating Scale was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change. Sixteen symptom constructs which have resulted fromExpand
Receptor specificity in phencyclidine psychosis
  • 1983
Physostigmine treatment of acute phencyclidine intoxication.
...
1
2
...