Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis

  title={Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis},
  author={A. Giannini and M. S. Eighan and R. H. Loiselle and M. Giannini},
  journal={The Journal of Clinical Pharmacology},
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below. 
Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.
The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role. Expand
Absence of response to histamine1 blockade in phencyclidine toxicity.
Chlorpromazine’s superiority over haloperidol in reducing anxiety and tension is contrary to what one would expect on the basis of anticholinergic activity alone. Expand
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A strong dopamine‐like agonist action at the functional high‐affinity state of the dopamine D2 receptor by the phencyclidine psychotomimetic is consistent with the dopamine hypothesis of psychosis. Expand
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Subjects who received desipramine showed a decrease in depressive symptoms after a 20–40 day period regardless of whether they abused PCP or cocaine. Expand
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The design of a “hybrid structure” having the desired properties of haloperidol and clozapine is proposed, with the intention being to find an optimal antipsychotic agent that exerts efficient therapeutic effects against both positive and negative symptoms of psychosis causing least possible side effects, such as in monotherapy. Expand
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The results of this study suggest that repeated administration of haloperidol may disrupt PCP's discriminative stimulus effects, although most rats were still able to discriminate the higher doses of PCP. Expand
The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia
To support the contention that NMDA receptor antagonist administration represents a viable model of schizophrenia, the behavioral and neurobiological effects of these drugs are discussed, especially with regard to differing profiles following single-dose and long-term exposure. Expand


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Twenty-four patients with phencyclidine intoxication were treated with either physostigmine (2 mg i.m.) or haloperidol (5 mg i.m.) based on the presence of delusions and/or hallucinations. SeveralExpand
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The binding of 3H-butyrophenones to dopamine receptors can be used for a radioreceptor assay that detects blood levels of all clinically used neuroleptics and their pharmacologically active metabolites and may facilitate routine monitoring of blood levels. Expand
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Guanine nucleotides shift this equilibrium toward the low affinity state, and they likely play an important role in the regulation of dopamine agonist-stimulated physiological responses. Expand
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Experimental A thin-layer chromatographic method for the simultaneous screening and confirmation of phencyclidine In urine specimens Is presented. Urine specimens ere made basic and extracted withExpand
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