Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis

@article{Giannini1984ComparisonOH,
  title={Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis},
  author={A. James. Giannini and M S Eighan and Robert H. Loiselle and Matthew C. Giannini},
  journal={The Journal of Clinical Pharmacology},
  year={1984},
  volume={24}
}
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below. 
Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.
TLDR
The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role.
Absence of response to histamine1 blockade in phencyclidine toxicity.
TLDR
Chlorpromazine’s superiority over haloperidol in reducing anxiety and tension is contrary to what one would expect on the basis of anticholinergic activity alone.
Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol.
TLDR
Results of haloperidol treatment of PHP psychosis were similar to previously published reports with phencyclidine (PCP) psychosis.
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
TLDR
While haloperidol was significantly more effective than ascorbic acid, the combination was significantlyMore effective than either used alone, suggesting this combination may have a specific antipsychotic role in the emergency treatment of PCP psychosis.
Dopamine agonist action of phencyclidine
TLDR
A strong dopamine‐like agonist action at the functional high‐affinity state of the dopamine D2 receptor by the phencyclidine psychotomimetic is consistent with the dopamine hypothesis of psychosis.
The Ideal Antipsychotic: Hybrid between Typical Haloperidol And the Atypical Clozapine Antipsychotic
TLDR
The design of a “hybrid structure” having the desired properties of haloperidol and clozapine is proposed, with the intention being to find an optimal antipsychotic agent that exerts efficient therapeutic effects against both positive and negative symptoms of psychosis causing least possible side effects, such as in monotherapy.
The psychotomimetic effects of PCP , LSD and MDMA : Pharmacological models of schizophrenia ?
TLDR
The primary question addressed herein, whether PCP-induced psychosis is a valid model of schizophrenia, gives rise to additional questions about the validity of ketamine challenge at subanaesthetic doses in humans as a model of PCP psychosis, and in turn, questions aboutThe validity of drug-induced changes in non-human animals (rodents, monkeys) treated with PCP and its analogues (ketamine or dizocilpine [MK-801]) as models of PCPs psychosis.
Effect of repeated haloperidol administration on phencyclidine discrimination in rats
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