Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis

  title={Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis},
  author={A. James. Giannini and M S Eighan and Robert H. Loiselle and Matthew C. Giannini},
  journal={The Journal of Clinical Pharmacology},
Two neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below. 
Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.
The authors suggest that DA-2 blockers, such as haloperidol or pimozide be employed as treatment of choice in PCP psychosis and tend to rule out a noradrenergic role.
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Chlorpromazine’s superiority over haloperidol in reducing anxiety and tension is contrary to what one would expect on the basis of anticholinergic activity alone.
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Results of haloperidol treatment of PHP psychosis were similar to previously published reports with phencyclidine (PCP) psychosis.
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While haloperidol was significantly more effective than ascorbic acid, the combination was significantlyMore effective than either used alone, suggesting this combination may have a specific antipsychotic role in the emergency treatment of PCP psychosis.
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A strong dopamine‐like agonist action at the functional high‐affinity state of the dopamine D2 receptor by the phencyclidine psychotomimetic is consistent with the dopamine hypothesis of psychosis.
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The primary question addressed herein, whether PCP-induced psychosis is a valid model of schizophrenia, gives rise to additional questions about the validity of ketamine challenge at subanaesthetic doses in humans as a model of PCP psychosis, and in turn, questions aboutThe validity of drug-induced changes in non-human animals (rodents, monkeys) treated with PCP and its analogues (ketamine or dizocilpine [MK-801]) as models of PCPs psychosis.
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Twenty-four patients with phencyclidine intoxication were treated with either physostigmine (2 mg i.m.) or haloperidol (5 mg i.m.) based on the presence of delusions and/or hallucinations. Several
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