Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.

@article{Kawakami2006ComparisonOH,
  title={Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.},
  author={Kazunobu Kawakami and Toshihisa Nagatomo and Haruhiko Abe and Kan Kikuchi and Hiroko Takemasa and Blake D. Anson and Brian P. Delisle and Craig T. January and Yasuhide Nakashima},
  journal={British journal of pharmacology},
  year={2006},
  volume={147 6},
  pages={642-52}
}
beta-Blockers are widely used in the treatment of cardiovascular diseases. However, their effects on HERG channels at comparable conditions remain to be defined. We investigated the direct acute effects of beta-blockers on HERG current and the molecular basis of drug binding to HERG channels with mutations of putative common binding site (Y652A and F656C). beta-Blockers were selected based on the receptor subtype. Wild-type, Y652A and F656C mutants of HERG channel were stably expressed in… CONTINUE READING

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