Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.

@article{Yano2006ComparisonOH,
  title={Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.},
  author={Tomonori Yano and Toshihiko Doi and Atsushi Ohtsu and Narikazu Boku and Kaoru Hashizume and Mamoru Nakanishi and Atsushi Ochiai},
  journal={Oncology reports},
  year={2006},
  volume={15 1},
  pages={
          65-71
        }
}
A monoclonal antibody to HER2 protein is widely used in the treatment of patients with HER2-overexpressing breast cancer and has also been found to exhibit antitumor activity in human gastric cancer cells that overexpress HER2. The purpose of this study was to evaluate the frequency of HER2 overexpression and concordance between the results for protein expression and gene amplification in both surgical and biopsy specimens of gastric cancer as assessed with two commercial kits, one for… CONTINUE READING

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