Comparison of H2-Receptor Antagonist-and Proton-Pump Inhibitor-Based Triple Regimens for the Eradication of Helicobacter Pylori in Chinese Patients with Gastritis or Peptic Ulcer

  title={Comparison of H2-Receptor Antagonist-and Proton-Pump Inhibitor-Based Triple Regimens for the Eradication of Helicobacter Pylori in Chinese Patients with Gastritis or Peptic Ulcer},
  author={Fulian Hu and Ju Jia and Y L Li and G B Yang},
  journal={Journal of International Medical Research},
  pages={469 - 474}
This study compared the efficacy of an H2-receptor antagonist (H2RA)- and a proton-pump inhibitor (PPI)-based triple regimen for the eradication of Helicobacter pylori infection. Chinese patients with H. pylori-associated gastritis or peptic ulcer were randomized to receive the H2RA-based triple regimen (20 mg famotidine, 1.0 g amoxicillin and 0.4 g metronidazole) or the PPI-based triple regimen (20 mg omeprazole, 1.0 g amoxicillin and 0.4 g metronidazole) both twice daily for 1 or 2 weeks… Expand
Systematic review and meta-analysis: triple therapy combining a proton-pump inhibitor, amoxicillin and metronidazole for Helicobacter pylori first-line treatment.
PAM was less efficacious than clarithromycin-including triple therapies, however, its efficacy was similar to that of PAC when drugs were administered for 14 days, although ITT cure rates did not reach 90%. Expand
A Meta-Analysis: Comparison of Esomeprazole and Other Proton Pump Inhibitors in Eradicating Helicobacter pylori
Esquomeprazole-based triple therapy may effectively eradicate H. pylori infection and promote favorable outcome with good tolerance and offers comparable efficacy to omeprazoles-based therapy. Expand
Optimum duration of regimens for Helicobacter pylori eradication.
The relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori was assessed to assess the relative risk and number needed to treat (NNT)/number needed to harm (NNTH) according to duration of therapy. Expand
Effect of gastric environment on Helicobacter pylori adhesion to a mucoadhesive polymer.
It is demonstrated that chitosan has the capacity to bind and kill H. pylori in a range of pHs independently of urea, which opens new perspectives for the application of chitOSan-based materials to the elimination of H.pylori gastric colonization, though pepsin might appear to be an obstacle. Expand
Comparison of Amoxicillin–Metronidazole Plus Famotidine or Lansoprazole for Amoxicillin–Clarithromycin–Proton Pump Inhibitor Treatment Failures for Helicobacter pylori Infection
The authors assessed the efficacy and safety of second‐line eradication using the H2‐receptor antagonist famotidine as a substitute for proton pump inhibitor. Expand
Xiao Chai Hu Tang for Peptic Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The findings show that XCHT can treat peptic ulcers as part of an alternative medicine approach and was superior to conventional pharmacotherapy (CPT) in improving the clinical efficacy rate. Expand
Method Development and Validation of Famotidine Oral Suspension by RP-HPLC Method
For perseverance of Famotidine a simple, fast and selective procedure were developed in drug substance and its pharmaceutical preparations. In the proposed project, a successful attempt has been madeExpand


[Proton-pump inhibitors versus H2-receptor antagonists in triple therapy for Helicobacter pylori eradication].
  • S. Kanayama
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 1999
The efficacy of H. pylori eradication regimens with H2-receptor antagonist or proton-pump inhibitor with two antibiotics is not significantly different. Expand
Eradication of Helicobacter pylori by a 1‐week course of famotidine, amoxicillin and clarithromycin
The data indicate that acid suppression is the crucial mechanism by which the activity of amoxicillin and clarithromycin against H. pylori is enhanced, whereas additional antimicrobial activity or other specific effects of PPIs seem to be less important. Expand
Factors influencing the eradication of Helicobacter pylori with triple therapy.
It is concluded that triple therapy is effective for eradication of H. pylori and that future studies need to take compliance into account for comparisons between regimens. Expand
Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.
In patients with recurrent duodenal ulcer, eradication of H. pylori by a regimen that does not have any direct action on the mucosa is followed by a marked reduction in the rate of recurrence, suggesting a causal role for H. Expand
Helicobacter pylori in peptic ulcer disease.
It is concluded that ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to antisecretory drugs whether on first presentation with the illness or on recurrence. Expand
Famotidine versus omeprazole in combination with clarithromycin and metronidazole for eradication of Helicobacter pylori—a randomized, controlled trial
: One‐week low‐dose triple therapy is currently considered the gold standard regimen for treatment of Helicobacter pylori infection. However, the mechanisms involved in the synergy betweenExpand
Head‐to‐head comparison of 1‐week triple regimens combining ranitidine or omeprazole with two antibiotics to eradicate Helicobacter pylori
: Triple therapies containing omeprazole and ranitidine have been shown to be equivalent in eradicating H. pylori infection, but have been assessed either separately or head‐to‐head, only in smallExpand
Gastric biopsy findings are classified according to the type of inflammation, regardless of other features, as "no inflammation", "chronic gastritis", or "active chronic gastritis" (ACG). Expand