Androgen-deprivation therapy (ADT) through surgical castration is equally effective as medical castration in controlling prostate cancer (PCa). However, the adverse effect profiles of both ADT groups have never been compared. To provide a comparative effectiveness analysis of the adverse effects of gonadotropinreleasing hormone agonists (GnRHa) vs bilateral orchiectomy in a homogeneous population. A population-based cohort of 3295 men with metastatic PCa between January 1995 and December 2009… CONTINUE READING