Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A

@inproceedings{Enkhbaatar2015ComparisonOG,
  title={Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A},
  author={Perenlei Enkhbaatar and C A Nelson and John R. Salsbury and Joseph R. Carmical and Karen E. O. Torres and David H. Herndon and Donald S. Prough and Liming Luan and Edward R Sherwood and Jan P Tuckermann},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in rodents have demonstrated the efficacy of TLR4 agonists as immunomodulators in models of infection. However, rodent models have been criticized for not mimicking important characteristics of… CONTINUE READING