Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose Inhaler

@article{Newman1995ComparisonOG,
  title={Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose Inhaler},
  author={Stephen Newman and Karen P Steed and Gerard Hooper and Anders K{\"a}ll{\'e}n and Lars Borgstr{\"o}m},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={231-236}
}
A comparison has been made of pulmonary deposition of terbutaline sulphate from a pressurized metered dose inhaler (pMDI), measured in 8 healthy male subjects by gamma scintigraphy and by a pharmacokinetic (charcoal-block) method, involving drug recovery in urine. Measurements were carried out with a pMDI at slow (27 1/min) and fast (151 1/min) inhaled flows and with Nebuhaler® large volume spacer device (average inhaled flow 171/min). Overall, the two methods did not differ significantly in… CONTINUE READING

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