Comparison of Drug Release From Metoprolol Modified Release Dosage Forms in Single Buffer versus a pH-Gradient Dissolution Test

@inproceedings{Klein2006ComparisonOD,
  title={Comparison of Drug Release From Metoprolol Modified Release Dosage Forms in Single Buffer versus a pH-Gradient Dissolution Test},
  author={Sandra Klein and Jennifer B. Dressman},
  year={2006}
}
Introduction Metoprolol is a cardioselective beta blocker that has been classified as a class I substance according to the Biopharmaceutics Classification Scheme BCS [1], meaning that it is highly soluble and highly permeable. The drug is readily and completely absorbed throughout the whole intestinal tract [2-4] but is subject to extensive firstpass… CONTINUE READING