Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of Klebsiella pneumoniae Responsible for Causing Pyogenic Liver Abscess

  title={Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of Klebsiella pneumoniae Responsible for Causing Pyogenic Liver Abscess},
  author={I. Russel Lee and E. El. Sng and K-O Lee and James Steven Molton and Monica Chan and Shirin Kalimuddin and Ezlyn Izharuddin and David Chien Boon Lye and Sophia Archuleta and Yunn‐Hwen Gan},
  journal={Frontiers in Cellular and Infection Microbiology},
  • I. R. Lee, E. Sng, Y. Gan
  • Published 7 September 2017
  • Medicine, Biology
  • Frontiers in Cellular and Infection Microbiology
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but… 
Protective Role of Kupffer Cells and Macrophages in Klebsiella pneumoniae-Induced Liver Abscess Disease
This study reveals the high capability of Kupffer cells to kill hvKp in vitro despite the presence of the bacterial hypermucoviscous capsule, in contrast to other macrophages, which were unable to phagocytose the bacteria efficiently.
Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus
ABSTRACT Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent
Clinical Characteristics of Diabetes Complicated by Bacterial Liver Abscess and Nondiabetes-Associated Liver Abscess
Clinical manifestations and laboratory results of BLA patients with and without diabetes mellitus were significantly different, and the symptoms of diabetics with BLA were serious.
The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
The impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients in aspirin users and non-users was investigated.
Clinical and computed tomography features of extended-spectrum β-lactamase-producing Klebsiella pneumoniae liver abscess
A retrospective analysis of data obtained from the medical records of patients with a first episode of KPLA, found that the ESBL-producing KPLA group had a significantly higher intensive care unit (ICU) admission rate and the presence of biliary disease was an independent risk factor.
A Molecular Interaction Map of Klebsiella pneumoniae and Its Human Host Reveals Potential Mechanisms of Host Cell Subversion
This study identifies some of the pivotal molecular targets of K. pneumoniae which primarily correlate to the physiological response of host during K. coli pneumoniae-mediated sepsis and identifies four pivotal K. tuberculosis-targeted transcription factors that are part of TTPPI and are involved in generating host’s transcriptional response to K.neumoniae.
Evaluating Different Virulence Traits of Klebsiella pneumoniae Using Dictyostelium discoideum and Zebrafish Larvae as Host Models
It is demonstrated that K. pneumoniae RYC492, but not the multiresistant strains 700603 and BAA-1705, is virulent to both host models and elicits a strong immune response, although no specific genes could be linked to its phagocytosis resistance, nor to the intracellular survival observed for the 700603 strain.
Perturbation of the mucosa-associated anaerobic gut microbiota in streptozotocin-induced diabetic rats
It is noteworthy that insulin treatment eliminated the Mycoplasma invasion in the duodenum and apparently restored the anaerobic environment in the mucosa, and in the ileum the abundance of the phylum Firmicutes increased in the diabetic samples, and after insulin treatment this increase was more significant.
The Pathogenic Bacteria of Deep Neck Infection in Patients with Type 1 Diabetes, Type 2 Diabetes, and Without Diabetes from Chang Gung Research Database
KP and Peptostreptococcus micros are the leading pathogens for both patients with T1DM-DNI and those with T2DM- DNI and Clinicians should beware of high serum levels of infection markers, which indicate potential mortality.


Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control.
CONTEXT Diabetes mellitus (DM) and capsular serotypes K1 and K2 Klebsiella pneumoniae have been identified as risk factors for liver abscess and complicated endophthalmitis. OBJECTIVE The objective
Interactions of Klebsiella pneumoniae with the Innate Immune System Vary in Relation to Clone and Resistance Phenotype
It is concluded that KPC-producing isolates seem to be highly virulent in a low-TNF-α-release environment, suggesting an immunoparalysis induction mechanism.
Do Neutrophils Play a Role in Establishing Liver Abscesses and Distant Metastases Caused by Klebsiella pneumoniae?
Serotype K1 Klebsiella pneumoniae is a major cause of liver abscesses and endophthalmitis. This study was designed to identify the role of neutrophils in the development of distant metastatic
Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
Hypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly
Interleukin-17 and lung host defense against Klebsiella pneumoniae infection.
  • P. YeP. Garvey J. Kolls
  • Medicine, Biology
    American journal of respiratory cell and molecular biology
  • 2001
It is shown that interleukin (IL)-17, a novel cytokine produced largely by CD4+ T cells, is produced in a compartmentalized fashion in the lung after challenge with Klebsiella pneumoniae and that optimally timed gene therapy with IL-17 may augment host defense against bacterial pneumonia.
A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?
K pneumoniae serotype K1 was significantly associated with liver abscess and the complication of endophthalmitis, especially in diabetic patients, and the use of ceftriaxone because of its higher concentration in the aqueous humor is suggested to decrease the chance of septic endophhalmitis.
Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis
The role of MRP8/14 is identified as key player in protective innate immunity during Klebsiella pneumonia using an established model characterized by gradual growth of bacteria with subsequent dissemination.
Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess.
K. pneumoniae genotype K1 is an emerging pathogen capable of causing catastrophic septic ocular or central nervous system complications from pyogenic liver abscess independent of underlying diseases in the host.
Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils.
It is suggested that enhancing neutrophil phagocytosis is a potential therapeutic approach for treatment of infection caused by carbapenem-resistant ST258K.