Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of Klebsiella pneumoniae Responsible for Causing Pyogenic Liver Abscess

@article{Lee2017ComparisonOD,
  title={Comparison of Diabetic and Non-diabetic Human Leukocytic Responses to Different Capsule Types of Klebsiella pneumoniae Responsible for Causing Pyogenic Liver Abscess},
  author={I. Russel Lee and E. El. Sng and K-O Lee and James Steven Molton and Monica Chan and Shirin Kalimuddin and Ezlyn Izharuddin and David Chien Boon Lye and Sophia Archuleta and Yunn‐Hwen Gan},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2017},
  volume={7}
}
  • I. R. Lee, E. Sng, Y. Gan
  • Published 7 September 2017
  • Medicine, Biology
  • Frontiers in Cellular and Infection Microbiology
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but… 
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  • Medicine, Biology
    American journal of respiratory cell and molecular biology
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