Comparison of Dermatopharmacokinetic vs. Clinicial Efficacy Methods for Bioequivalence Assessment of Miconazole Nitrate Vaginal Cream, 2% in Humans

Abstract

Purpose. To compare the dermatopharmacokinetic vs. clinical trial methods for bioequivalence assessment of two miconazole nitrate vaginal cream, 2% products. Methods. The dermatopharmacokinetic method determined the bioequivalence of two products simultaneously in 24 healthy subjects, as a function of Cmax and AUC0- t parameters using miconazole nitrate… (More)
DOI: 10.1023/A:1014486716823

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@article{Pershing2002ComparisonOD, title={Comparison of Dermatopharmacokinetic vs. Clinicial Efficacy Methods for Bioequivalence Assessment of Miconazole Nitrate Vaginal Cream, 2% in Humans}, author={Lynn K. Pershing and Judy L. Corlett and Joel L. Nelson}, journal={Pharmaceutical Research}, year={2002}, volume={19}, pages={270-277} }