Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B).

@article{Robinson2017ComparisonOD,
  title={Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B).},
  author={Jennifer A. Robinson and Mark A Marzinke and Rahul P Bakshi and Edward J. Fuchs and Christine L Radebaugh and Wutyi S. Aung and Hans M. L. Spiegel and Jenell Sheree Coleman and Lisa Cencia Rohan and Craig W Hendrix},
  journal={AIDS research and human retroviruses},
  year={2017},
  volume={33 4},
  pages={339-346}
}
While preexposure prophylaxis with oral tenofovir/emtricitabine reduces HIV acquisition rates, poor adherence to and acceptability of vaginal gels and the potential for evolving drug resistance have led to development of vaginal film formulations and other antiretroviral drugs, respectively, including the non-nucleoside reverse transcriptase inhibitor dapivirine. In this two-arm crossover study of a novel fast-dissolving dapivirine film and a previously studied semisolid dapivirine gel, 10… CONTINUE READING
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