Comparison of DNA polymerase and radioimmune assays for the detection of hepatitis B antigens and antibodies.

Abstract

In acute cases of hepatitis, DNA polymerase activity was found 2 to 3 times more frequently than positive radioimmunoassay. For each case the DNA polymerase reactivity was shown to be associated with hepatitis B antigens. Inhibitors to this DNA polymerase, with properties of IgM and IgG antibody, were found in 13 of 34 cases of acute hepatitis but only in 1 case out of 22 of cirrhosis. During the course of the acute disease these antibodies were detected 3 times more frequently than those to HBs antigen; the two types of antibodies were almost always found separately in different patients, those to DNA polymerase were apparently transient and developed earlier since they were found as early as 3 days after the clinical onset and no later than the 6th week following the onset.

Cite this paper

@article{Cappel1975ComparisonOD, title={Comparison of DNA polymerase and radioimmune assays for the detection of hepatitis B antigens and antibodies.}, author={Roger Cappel and G. Clinet and Laura Thiry}, journal={Developments in biological standardization}, year={1975}, volume={30}, pages={186-92} }