Comparison of DNA lesions and cytotoxicity induced by calcium chromate in human, mouse, and hamster cell lines.

@article{Sugiyama1986ComparisonOD,
  title={Comparison of DNA lesions and cytotoxicity induced by calcium chromate in human, mouse, and hamster cell lines.},
  author={Masanori Sugiyama and Xin Wei Wang and M da G Costa},
  journal={Cancer research},
  year={1986},
  volume={46 9},
  pages={4547-51}
}
DNA lesions, cytotoxicity, and cellular uptake of CaCrO4 were compared in Chinese hamster ovary, in mouse embryo fibroblast C3H10T1/2, and in human osteosarcoma cells. The concentration of CaCrO4 that reduced colony formation by 50% was 2- or 3-fold less in human osteosarcoma cells than in C3H10T1/2 or Chinese hamster ovary cells. Alkaline elution studies showed that CaCrO4 induced DNA single strand breaks in a concentration dependent manner in all three cell lines. However, the human cells… CONTINUE READING
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Toxicity and Carcinogenicity of essential and non-essential metals

  • M. Costa, A. J. Kraker, S. R. Patierno
  • Progress in Clinical Biochemistry
  • 1984
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