Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose.

@article{Mauthe1999ComparisonOD,
  title={Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose.},
  author={Robert J Mauthe and Karen H. Dingley and Steven H. Leveson and Stewart P. H. T. Freeman and Robert J Turesky and Ronald Colin Garner and Kenneth W. Turteltaub},
  journal={International journal of cancer},
  year={1999},
  volume={80 4},
  pages={539-45}
}
[2-14C]2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was administered orally (304 ng/kg body-weight dose based upon an average 70-kg-body-weight subject) to 5 human colon-cancer patients (58 to 84 years old), as well as to F344 rats and B6C3F1 mice. Colon tissue was collected from the human subjects at surgery and from the rodents 3.5 to 6 hr after administration. Colon DNA-adduct levels and tissue available doses were measured by accelerator mass spectrometry (AMS). The mean levels of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
14 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…