Comparison of Cytotoxicity of Aminoglycoside Antibiotics Using a Panel Cellular Biotest System

@article{Chernikov2003ComparisonOC,
  title={Comparison of Cytotoxicity of Aminoglycoside Antibiotics Using a Panel Cellular Biotest System},
  author={Vitaliy Chernikov and Sergey M Terekhov and Tatiana Krokhina and Sergey S. Shishkin and Tatiana D. Smirnova and Elena Aleksandrovna Kalashnikova and N. V. Adnoral and L. B. Rebrov and Yu. I. Denisov-Nikol'skii and Viktor Alexandrovich Bykov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2003},
  volume={135},
  pages={103-105}
}
The cytotoxicity of four aminoglycoside antibiotics was studied by estimation of the dose-effect relationship using a panel cellular biotest system including cell cultures for test objects. The cultures represented 4 differentiation types: normal human fibroblasts and myoblasts, human or Syrian hamster hepatoma cells, and mouse/mouse hybridoma cells. It was found that three widely used antibiotics gentamicin, kanamycin, and neomycin exhibit similar, but not identical cytotoxicity parameters and… CONTINUE READING
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