Comparison of Child-Pugh (CP) criteria and NCI organ dysfunction working group (NCI-ODWG) criteria for hepatic dysfunction (HD): Implications for chemotherapy dosing.

@article{Patel2004ComparisonOC,
  title={Comparison of Child-Pugh (CP) criteria and NCI organ dysfunction working group (NCI-ODWG) criteria for hepatic dysfunction (HD): Implications for chemotherapy dosing.},
  author={Hetul J Patel and Merrill J. Egorin and Scot C. Remick and Daniel L. Mulkerin and Chris H M Takimoto and James H. Doroshow and Douglas P Potter and S Percy Ivy and Anthony J. Murgo and Ramesh K. Ramanathan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 14_suppl},
  pages={6051}
}
6051 Background: Patients with HD may require drug dose modification based on the severity of HD. HD is often assessed using CP criteria, the use of which is advocated by the FDA. CP criteria, originally developed for patients with end-stage liver disease, has 5 components -total bilirubin (TB), albumin, prothrombin time, ascites & encephalopathy. NCI-ODWG sponsored trials have used different criteria which utilize two objective and readily measurable laboratory parameters specifically - TB… CONTINUE READING