Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice.

Abstract

Cerebellin precursor protein 1 (Cbln1) is the prototype of a family of secreted neuronal glycoproteins (Cbln1-4) and its genetic elimination results in synaptic alterations in cerebellum (CB) and striatum. In CB, Cbln1 acts as a bi-functional ligand bridging pre-synaptic β-neurexins on granule cells to post-synaptic Grid2 on Purkinje neurons. Although much… (More)
DOI: 10.1111/j.1471-4159.2011.07604.x

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