Comparison of Canine and Human Gastrointestinal Physiology

@article{Dressman2004ComparisonOC,
  title={Comparison of Canine and Human Gastrointestinal Physiology},
  author={Jennifer Dressman},
  journal={Pharmaceutical Research},
  year={2004},
  volume={3},
  pages={123-131}
}
  • J. Dressman
  • Published 1 June 1986
  • Biology, Medicine
  • Pharmaceutical Research
In this review, the gross physiology of the gastrointestinal tract of dogs is compared with that of humans, particularly as it pertains to drug absorption and dosage-form performance. Gastrointestinal (GI) motility and pH are the main parameters considered. Although similar motility patterns and pH profiles prevail in the two species for the most part, there are some differences that could affect the time profile and extent of drug absorption. These include slower gastric emptying in the fed… Expand
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Drug solubility classification in the dog.
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References

SHOWING 1-10 OF 47 REFERENCES
Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans.
TLDR
Results indicated that in the quiescent phase, gastric pH in the dogs was significantly higher than in humans, with an average canine intestinal pH of 7.3 +/-0.09 versus 6.0 +/- 0.14 for humans. Expand
Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.
TLDR
Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different, while the percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration. Expand
The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)
TLDR
The transit from the stomach through the small intestine to the colon was influenced by the nature of the meal taken shortly before dosing, and the concept of the ‘reserve length’ for drug absorption was discussed. Expand
A comparative study of the gastrointestinal transit of a pellet and tablet formulation
TLDR
The transits of the formulations were found to be highly dependent on food intake and there was a good correlation between transit times (gastric emptying, arrival at colon) and the calorific value of the meal taken shortly before dosing. Expand
Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition.
TLDR
The data suggest that the GRT of the Heidelberg capsule is a marker of the interdigestive migrating myoelectric complex in humans, which can be markedly delayed by frequent feedings with solids, and the interDigestive migratory complex is delayed by both liquid and solid meals. Expand
Apparent dose-dependent absorption of chlorothiazide in dogs
TLDR
The results suggest that chlorothiazide absorption is dose dependent and apparently site specific. Expand
Intestinal transit of solid and liquid components of a meal in health
Abstract The aim of this study was to test the hypothesis that, under physiologic conditions, the human small bowel discriminates between the solid and aqueous components of chyme, that is, that in aExpand
Effect of size and density on canine gastric emptying of nondigestible solids.
TLDR
Both sphere size and density affect their emptying in the presence of food, and both are associated with dogs with chronic duodenal fistulas. Expand
Canine intestinal transit and digestion of radiolabeled liver particles.
TLDR
Flood flows have a major effect on transit and digestion of food particles in the small intestine and were associated with decreasing digestion or fragmentation of liver particles. Expand
Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea
TLDR
Overall stool weight for 48 hr after ingestion of the meal was inversely related to whole gut transit time but not to small intestinal transit time suggesting that the tendency to develop diarrhea in response to a meal containing unabsorbable carbohydrate depends more on the lack of colonic accommodation than on the rate of small intestine transit. Expand
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3
4
5
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