Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease

@inproceedings{Breden2011ComparisonOA,
  title={Comparison of Antibody Repertoires Produced by HIV-1 Infection, Other Chronic and Acute Infections, and Systemic Autoimmune Disease},
  author={Felix Breden and Christa Lepik and Nancy S. Longo and Marinieve Montero and Peter E Lipsky and Jamie K. Scott},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Antibodies (Abs) produced during HIV-1 infection rarely neutralize a broad range of viral isolates; only eight broadly-neutralizing (bNt) monoclonal (M)Abs have been isolated. Yet, to be effective, an HIV-1 vaccine may have to elicit the essential features of these MAbs. The V genes of all of these bNt MAbs are highly somatically mutated, and the V(H) genes of five of them encode a long (≥ 20 aa) third complementarity-determining region (CDR-H3). This led us to question whether long… CONTINUE READING
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