Comparison of ARMS and direct sequencing for detection of EGFR mutation and prediction of EGFR-TKI efficacy between surgery and biopsy tumor tissues in NSCLC patients

@article{Shaozhang2014ComparisonOA,
  title={Comparison of ARMS and direct sequencing for detection of EGFR mutation and prediction of EGFR-TKI efficacy between surgery and biopsy tumor tissues in NSCLC patients},
  author={Zhou Shaozhang and Zhou Ming and Peng Hai-yan and Zeng Ai-ping and Yu Qitao and Song Xiang-qun},
  journal={Medical Oncology},
  year={2014},
  volume={31},
  pages={1-9}
}
The relationship between epidermal growth factor receptor (EGFR) mutation status and EGFR-tyrosine kinase inhibitors (TKI) efficacy in non-small cell lung cancer (NSCLC) patients has been well established. However, there is no available standard to define the optimal testing method and specimen type required for the detection of EGFR mutations. In this study, we compare results of ADx-amplification refractory mutation system (ARMS) and direct sequencing for the detection of EGFR mutation and… CONTINUE READING

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