Comparison of ANG II in fetal and pregnant sheep: metabolic clearance and vascular sensitivity.

@article{Rosenfeld1995ComparisonOA,
  title={Comparison of ANG II in fetal and pregnant sheep: metabolic clearance and vascular sensitivity.},
  author={Charles R Rosenfeld and A Gresores and Timothy A. Roy and Ronald R Magness},
  journal={The American journal of physiology},
  year={1995},
  volume={268 2 Pt 1},
  pages={E237-47}
}
Fetal sheep appear less responsive to infused angiotensin II (ANG II) than pregnant ewes. This may reflect a greater fetal metabolic clearance rate (MCRANGII) and thus lower plasma ANG II levels. We therefore determined fetal MCRANGII, half-life (T1/2), and placental removal of ANG II. Fetal sheep (n = 13; 113-139 days of gestation) received 0.573-5.73 micrograms ANG II/min iv for 30 min while arterial pressure and heart rate were monitored. Serial blood samples were obtained before and during… CONTINUE READING

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