Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility.

@article{Dowd2005ComparisonO6,
  title={Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in rats using a lateralised nose-poking task with low stimulus-response compatibility.},
  author={Eil{\'i}s Dowd and Stephen B. Dunnett},
  journal={Behavioural brain research},
  year={2005},
  volume={165 2},
  pages={181-6}
}
Experimental therapies for Parkinson's disease are commonly validated in unilateral rat lesion models using simple tests of motor asymmetry such as rotation. However, the human disorder is considerably more complex than this, and alternative tests that yield a more relevant evaluation of the lesion-induced deficit could provide a powerful behavioural tool for analysis of novel therapies. This study evaluated the potential of a lateralised nose-poking task for detailed assessment of the deficit… CONTINUE READING
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