Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.

@article{Fang2008ComparisonO5,
  title={Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy.},
  author={Yi-Ping Fang and Y N Tsai and Pao-chu Wu and Yaw-Bin Huang},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={356 1-2},
  pages={144-52}
}
Topical photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative therapy for many non-melanoma skin cancers. The major limitation of this therapy, however, is the low permeability of ALA through the stratum corneum (SC) of the skin. The objective of the present work was to characterize ethosomes containing ALA and to enhance the skin production of protoporphyrin IX (PpIX), compared to traditional liposomes. Results showed that the average particle sizes of the ethosomes… CONTINUE READING

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