Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity

  title={Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity},
  author={Cem Doğan and Z{\"u}beyde Bayram and Murat Çap and Flora {\"O}zkalaycı and Tuba Unkun and Emrah Erdoğan and Abdulkadir Uslu and Rezzan Deniz Acar and Busra Guvendi and {\"O}zg{\"u}r Yaşar Akbal and Ali Karag{\"o}z and Aykun Hakgor and Ahmet Karaduman and Samet Uysal and Ahmet Çağrı Aykan and Ci̇hangi̇r Kaymaz and Nihal {\"O}zdemir},
Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion… 

Figures and Tables from this paper

Systemic Vulnerability, as Expressed by I-CAM and MMP-9 at Presentation, Predicts One Year Outcomes in Patients with Acute Myocardial Infarction—Insights from the VIP Clinical Study
High levels of I-CAM and MMP-9 were the most powerful predictors for recurrent events after AMI for the overall study population, and Inflammatory biomarkers assayed during the acute phase of AMI presented a more powerful predictive capacity for MACE than the LVEF.
Immediate versus staged revascularisation of non-culprit arteries in patients with acute coronary syndrome: a systematic review and meta-analysis
Although there is robust evidence that revascularisation of non-culprit vessels should be pursued in patients presenting with an acute coronary syndrome (ACS) and multivessel coronary artery disease


Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction.
Patients with extensive CAD in vessels remote from the infarct-related artery have reduced reperfusion success and an adverse prognosis following primary PCI in AMI and future studies regarding the optimal treatment of patients with multivessel disease and AMI are warranted.
Staged versus One-Time Complete Revascularization with Percutaneous Coronary Intervention in STEMI Patients with Multivessel Disease: A Systematic Review and Meta-Analysis
The staged strategy for non-culprit lesions improved short- and long-term survival and should remain the standard approach to primary PCI in patients with STEMI; one-time complete multivessel PCI may be associated with greater mortality risk.
A comparison of multivessel and culprit vessel percutaneous coronary intervention in non-ST-segment elevation acute coronary syndrome patients with multivessel disease: a meta-analysis.
  • Y. Qiao, Weiju Li, Changsheng Ma
  • Medicine
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
  • 2015
No significant difference was demonstrated in the long-term risk of myocardial infarction and mortality between multivessel PCI and culprit vessel PCI, suggesting multives Sel PCI may be a safe and reasonable option for NSTE-ACS patients with multivessels disease.
Multivessel Versus Culprit Vessel–Only Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction: Insights From the TRANSLATE‐ACS Observational Study
Among patients with acute MI who have multivessels disease, multivessel PCI was associated with lower risk of all‐cause readmission at 6 weeks and lower riskof major adverse cardiovascular events at 6week and 1 year, however, similar short‐ and long‐term angina frequencies were noted.