Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans.


OBJECTIVE CT is considered the gold standard imaging modality for measurement of visceral adipose tissue area. However, as CT imaging exposes subjects to ionising radiation, a comparable imaging technique without this exposure is desirable, such as MRI. Therefore, we compared the agreement of measures of visceral adipose tissue and subcutaneous adipose tissue area from single-slice images obtained at the umbilicus using a 3 T MRI scanner with single-slice images obtained via CT scan. METHODS 64 images were obtained from 27 subjects who underwent MRI and CT scanning on the same day, after 10-12 hours of fasting. Visceral and subcutaneous adipose tissue depots were manually separated and quantified using a multimodality image-processing software program. RESULTS We found good agreement between CT and MRI for the measurement of both visceral adipose tissue and subcutaneous adipose tissue. Bland-Altman difference analysis demonstrated a mean bias of -2.9% (as a portion of total abdominal area) for visceral adipose tissue and +0.4% for subcutaneous adipose tissue, as measured by MRI compared with CT. CONCLUSION MRI is a safe, accurate and precise imaging modality for measuring both visceral and subcutaneous adipose tissue, making it a favourable alternative to CT for quantification of these adipose depots.

DOI: 10.1259/bjr/57987644
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@article{Klopfenstein2012ComparisonO3, title={Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans.}, author={Bethany J Klopfenstein and Mi Sung Kim and Christine M Krisky and Jerzy Szumowski and William D. Rooney and Jonathan Q . Purnell}, journal={The British journal of radiology}, year={2012}, volume={85 1018}, pages={e826-30} }