Comparison of (64)Cu-complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability.

@article{Cooper2012ComparisonO,
  title={Comparison of (64)Cu-complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability.},
  author={Maggie Cooper and Michelle T Ma and Kavitha Sunassee and Karen Shaw and Jennifer D Williams and Rowena L. Paul and Paul S Donnelly and Philip J Blower},
  journal={Bioconjugate chemistry},
  year={2012},
  volume={23 5},
  pages={1029-39}
}
High radiolabeling efficiency, preferably to high specific activity, and good stability of the radioimmunoconjugate are essential features for a successful immunoconjugate for imaging or therapy. In this study, the radiolabeling efficiency, in vitro stability, and biodistribution of immunoconjugates with eight different bifunctional chelators labeled with (64)Cu were compared. The anti-CD20 antibody, rituximab, was conjugated to four macrocyclic bifunctional chelators (p-SCN-Bn-DOTA, p-SCN-Bn… CONTINUE READING