Comparison between tumor pH and cell sensitivity to heat in RIF-1 tumors.

We have performed a direct comparison between tumor pH and cell survival in heated RIF-1 tumors growing intradermally in thighs of C3H mice. The pH of individual tumors was measured by inserting a microelectrode into the tumor center. After pH measurements, the tumor-bearing legs were heated in a water bath (44.6 degrees C, 30 min). We then excised a small… (More)