• Corpus ID: 4922580

Comparison between thermoregulatory effects mediated by alpha 1- and alpha 2-adrenoceptors in normothermic and febrile rabbits.

  title={Comparison between thermoregulatory effects mediated by alpha 1- and alpha 2-adrenoceptors in normothermic and febrile rabbits.},
  author={Z. Szreder},
  journal={General pharmacology},
  volume={24 4},
  • Z. Szreder
  • Published 1993
  • Medicine
  • General pharmacology
1. In order to better delineate the profile of thermoregulatory action of alpha 1-adrenoceptor antagonists; corynanthine (CRN) and BMY 20064 (BMY), and alpha 2-adrenoceptor agonist; medetomidine (MDT) and B-HT 920 (BHT), the effect of intravenous administration of two doses of these drugs on rectal (Tre) and ear skin (Te) temperatures, metabolic rate (M), respiratory evaporative heat loss (Eres) and respiratory rate (Rr) were examined in febrile and non-febrile rabbits. 2. Results indicate that… 
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