Comparison between theophylline and spironolactone in the management of cirrhotic ascites: a randomized controlled study.


BACKGROUND It has been suggested that adenosine is involved in the renal haemodynamic and tubular abnormalities observed in cirrhosis. Low-dose theophylline is an adenosine antagonist and recent studies have shown that this drug can improve renal blood flow and sodium excretion in cirrhotic patients. METHODS Fifteen patients with newly diagnosed cirrhotic… (More)


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