Comparison between the cytogenetic test for fragile X and the molecular analysis of the FMR-1 gene in Japanese mentally retarded individuals.

@article{Hofstee1994ComparisonBT,
  title={Comparison between the cytogenetic test for fragile X and the molecular analysis of the FMR-1 gene in Japanese mentally retarded individuals.},
  author={Y Hofstee and Tadao Arinami and Hideo Hamaguchi},
  journal={American journal of medical genetics},
  year={1994},
  volume={51 4},
  pages={466-70}
}
The prevalence of the fragile X syndrome has been estimated by the results of population studies in which the disease was mostly diagnosed by cytogenetic examinations. To examine the reliability of the cytogenetic analysis for the estimation of the prevalence of the fragile X syndrome, the CGG repeat in the FMR-1 gene was assayed by Southern blot hybridization and polymerase chain reaction (PCR) in an institutionalized group of mentally retarded individuals consisting of 305 males and 129… CONTINUE READING

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