Comparison between recombinant P450s and human liver microsomes in the determination of cytochrome P450 Michaelis-Menten constants.

@article{Youdim2010ComparisonBR,
  title={Comparison between recombinant P450s and human liver microsomes in the determination of cytochrome P450 Michaelis-Menten constants.},
  author={Kuresh A Youdim and Raksha Dodia},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2010},
  volume={40 4},
  pages={235-44}
}
Non-linear dose-exposure (supra-proportionality) occurs when plasma drug concentrations increase in a non-linear fashion with increasing dose. To predict the likelihood of this, an understanding is required of the K(M), which reflects a drug ability to saturate a specific enzyme involved in its metabolism. This study assessed the accuracy of K(M) and V(max… CONTINUE READING